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  往期阅览 · All Issues-> 2026年 · 2026  
临床用药研究2026年第2卷第2期第17-21页,pISSN 3105-6741、eISSN 3105-675X 发布者:Quest Press 发布日期:2026/9/3
Open Access 浏览41

 

二羟丙茶碱联合头孢曲松钠治疗老年慢性支气管炎 急性发作的临床疗效分析


宋腾腾

河南中医药大学第五临床医学院(郑州人民医院),河南郑州, 450003

摘要:目的:探讨二羟丙茶碱联合头孢曲松钠用于老年慢性支气管炎急性发作患者的临床治疗效果。 方法:选取本院收治老年慢性支气管炎急性发作患者 196 例展开研究,病例治疗时间为 2024 年 1 月— 2024 年 12 月,采用随机数字表法平均分入观察组(98 例)与对照组(98 例)。对照组予以单纯头孢曲松 钠静脉抗感染治疗,观察组在对照组治疗方案上加用二羟丙茶碱静脉滴注;两组均规范开展氧疗、祛痰 等基础对症干预,疗程 14 d。对比两组临床治疗总有效率,检测并比较治疗前后肺功能指标 和血清炎 症标志物 ,记录咳嗽、咳痰、肺部啰音、喘息等症状体征消退时间。结果:观察组治疗总有效率 、肺 功能指标和血清炎症标志物均优于对照组(P<0.05);观察组咳痰、咳嗽、肺部啰音、喘息消退时间均 显著短于对照组(P<0.05)。结论:二羟丙茶碱联合头孢曲松钠可显著提升老年慢性支气管炎急性发作 患者临床疗效,改善肺通气功能,快速缓解临床症状,用药安全性良好,适合老年人群临床推广应用。

关健词:老年慢性支气管炎;急性发作;二羟丙茶碱;头孢曲松钠;肺功能;炎症因子
Clinical Efficacy Analysis of Diprophylline Combined with Ceftriaxone Sodium in the Treatment of Acute Exacerbation of Chronic Bronchitis in Elderly Patients

Tengteng Song

The Fifth Clinical Medical College of Henan University of Chinese Medicine(Zhengzhou People's Hospital), Zhengzhou 450003,Henan,China

Abstract:Objective:To investigate the clinical therapeutic effect of diprophylline combined with ceftriaxone sodium in elderly patients with acute exacerbation of chronic bronchitis.Methods:A total of 196 elderly patients diagnosed with acute exacerbation of chronic bronchitis admitted to our hospital from January 2024 to December 2024 were enrolled in this study. The subjects were randomly divided into an observation group(98 cases)and a control group(98 cases)by the random number table method. The control group received intravenous anti-infective monotherapy with ceftriaxone sodium,while the observation group was additionally administered intravenous drip of diprophylline on the basis of the control group’s regimen. Standard basic symptomatic interventions including oxygen therapy and expectorant treatment were performed in both groups,with a treatment course of 14 days. The overall clinical effective rate was compared between the two groups; pulmonary function indicators and serum inflammatory markers were detected and compared before and after treatment;the resolution time of symptoms and signs such as cough,expectoration,pulmonary rales and wheezing was recorded.Results: The observation group achieved superior overall treatment effective rate,better pulmonary function indicators and more favorable serum inflammatory marker levels compared with the control group(P<0.05). The resolution time of cough,expectoration,pulmonary rales and wheezing in the observation group was significantly shorter than that in the control group (P<0.05).Conclusion:The combination of diprophylline and ceftriaxone sodium can significantly improve clinical efficacy,ameliorate pulmonary ventilation function and rapidly relieve clinical symptoms in elderly patients with acute exacerbation of chronic bronchitis. This combined regimen exhibits favorable medication safety and is worthy of clinical promotion among elderly populations.


Keywords : Elderly chronic bronchitis;Acute exacerbation;Diprophylline;Ceftriaxone sodium;Pulmonary function; Inflammatory factors


参考文献
[1] 顾龙强.金荞麦胶囊联合盐酸氨溴索及二羟丙茶碱治 疗慢性阻塞性肺疾病急性加重期的临床观察[J].实用 中西医结合临床,2026,26(04):50-53.
[2] 王艳,李娟,张伟.二羟丙茶碱辅助治疗老年慢性支气 管炎急性发作对患者肺功能及炎症因子的影响[J].临 床合理用药杂志,2024,17(12):63-65.
[3] 刘军,陈丽,周明.头孢曲松钠抗感染治疗老年下呼吸 道感染的疗效及安全性研究[J].中国实用医药,2024, 19(08):102-105.
[4] 张海涛,孙晓燕.二羟丙茶碱联合抗菌药物治疗慢性支 气管炎急性发作的临床效果及对气道炎症的抑制作 用[J].医学信息,2024,37(15):112-115.
[5] 李明杰,王淑敏.老年慢性支气管炎急性发作规范化治 疗中抗菌联合平喘药物的应用价值[J].国际老年医学 杂志,2023,44(06):682-685.
[6] 王芳杰,崔虎啸,史广超.三子止咳胶囊联合二羟丙茶 碱治疗慢性支气管炎急性发作的临床研究[J].现代药 物与临床,2023,38(09):1821-1824.
[7] 周峻林,刘鸿宇,龙辰娟,等.噻托溴铵粉吸入剂联合 二羟丙茶碱注射液治疗慢性阻塞性肺疾病的效果及 对肺功能的影响[J].临床合理用药杂志,2023,16(23): 59-62.
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